Cooking chicken can be a daunting task, especially when it comes to getting the right temperature and time. Knowing how long to cook chicken breast in oven at 375°F is key to ensuring that your dish turns out perfectly cooked, juicy and flavorful every single time!
Whether you’re a professional chef or just someone who loves to experiment in the kitchen, this blog post will provide step-by-step tips for cooking delicious chicken breasts in an oven at 375°F. Read on for expert advice from experienced cooks as well as some helpful hints on seasoning and selecting the ideal bird for a mouthwatering result.
Get ready to master mouthwatering home-cooked meals with these insider secrets of how long to cook chicken breast in oven at 375!
Is It Safe to Cook Chicken Breast in Oven at 375?
Yes! It’s perfectly safe to cook chicken breast in the oven at 375°F. In fact, this method is considered one of the safest and most effective ways to cook poultry.
Moreover, cooking at 375 in comparison with cooking chicken breast at 400 – 450 F can help keep the chicken moist, tender, and juicy. The higher temp is just good for hastening cooking time, this is also a weak point because you need to keep an eye on your dish constantly.
How Long to Cook Chicken Breast in Oven at 375?
Generally, the answer for how long to cook chicken breast in oven at 375 depends on how thick and the doneness you want:
- 4 ounces of chicken breast will take about 20-25 minutes
- 6 ounces of chicken breast will take about 25-30 minutes
- 8 ounces of chicken breast will take about 30-35 minutes
Keep in mind that these are just general guidelines, so always use a food thermometer to check the temperature. The safe internal temperature for cooked poultry is 165°F (following USDA).
Now it’s time to check out the cooking time when it comes to different types:
Type #1: Regular chicken breast
For regular chicken breasts, when it comes to how long to cook chicken breast in oven at 375, the cooking time will be around 20-25 minutes. This is how long it typically takes to cook a 4-ounce piece at 375°F. For larger pieces (6-8 ounces), you may need to add an additional 5-10 minutes of cooking time.

Type #2: Bone-in chicken breast
For bone-in chicken breast, the cooking time will be around 25-30 minutes. Keep in mind that bones and skin typically take longer to cook, so you may need to add an additional 5-10 minutes of cooking time for larger pieces (6-8 ounces).
Type #3: Boneless skinless chicken breast
If you’re using boneless skinless chicken breast and wonder about how long to cook chicken breast in oven at 375, the cooking time will be around 25-30 minutes. For larger pieces (6-8 ounces), you may need to add an additional 5-10 minutes of cooking time.

Type #4: Marinated chicken breast
If you’re marinating the chicken breast, the cooking time will be around 25-30 minutes. Keep in mind that marinated chicken may take a bit longer to cook, so you may need to add an additional 5-10 minutes of cooking time for larger pieces (6-8 ounces).
Type #5: Stuffed chicken breast
For stuffed chicken breasts, the cooking time will be around 30-35 minutes. As always, use a food thermometer to check that the internal temperature of the chicken has reached 165°F.

Type #6: Frozen chicken breast
If you’re cooking frozen chicken breast, the cooking time – how long to cook chicken breast in oven at 375 – will be around 30-35 minutes. Keep in mind that frozen chicken may take a bit longer to cook, so you may need to add an additional 5-10 minutes of cooking time for larger pieces (6-8 ounces).
Signs to Know My Chicken Breast is Done Cooking
Checking the temperature with a food thermometer is the best way to know if your chicken breast has reached the safe internal cooking temperature of 165°F. Other indications that it’s done include:
- The juices run clear when you cut into the thickest part of the chicken
- It has an even, golden-brown color
- It’s no longer pink inside
Pro Tips for A Juicy Tender Chicken Breast in Oven at 375
Want to make sure your chicken breast is perfectly cooked at 375? Here are some key tips from experienced cooks:

- Start with a high-quality fresh or frozen chicken breast
- Thaw the chicken thoroughly before cooking (if using frozen)
- Make sure to season both sides of the chicken for maximum flavor
- Cover the chicken with foil or parchment paper before baking
- Add a splash of liquid (such as chicken stock, white wine, or olive oil) for moisture
- Check the internal temperature with a food thermometer to ensure it’s safely cooked
- Let it rest for at least 5 minutes after cooking to reabsorb the juices
Is Chicken Breast Good for Diabetes?
Yes, chicken breast is an excellent choice for people with diabetes as it’s lean and low in saturated fat. Be sure to pair your chicken with whole grains and plenty of vegetables to help regulate blood sugar levels.
FAQs
Is it better to cook chicken breast at 375 or 400?
It depends on how quickly you want your chicken breast to cook. Cooking chicken at 375°F will result in a tender, juicy finished product. Cooking it at 400°F may cause the outside of the chicken to crisp up faster, but it could also dry out more quickly if left in the oven too long.
Does cooking chicken breast at 375 make it more tender?
Yes! Cooking chicken at 375°F will result in a tender, juicy finished product. This is the ideal temperature to cook chicken and keep it from drying out. Just be sure to check the internal temperature with a food thermometer before serving—the safe internal cooking temperature for poultry is 165°F.
How to make chicken breast more tender?
Marinating chicken is one of the best ways to make it more tender. You can use a store-bought marinade or create your own with oil, acidic ingredients (like vinegar, lemon juice, or lime juice), herbs and spices. Another way to keep chicken from drying out is cooking it at 375°F instead of 400°F. This will ensure that it remains juicy and tender while still cooking thoroughly.
Why is my chicken breast dry?
If your chicken breast is dry, it could be because it was overcooked or cooked at too high of a temperature. To prevent this from happening, make sure to season both sides of the chicken before cooking and always check the internal temperature with a food thermometer. Cooking chicken at 375°F instead of 400°F will also help ensure that it stays juicy and tender.
Conclusion
Cooking chicken breast in the oven at 375°F is an easy and delicious way to prepare it. Depending on the type of chicken you’re using, the cooking time can range from 20-30 minutes. Use a food thermometer to ensure that your chicken has reached the safe internal temperature of 165°F. Marinating or basting your chicken will also help make it more tender. Enjoy your dish with us dixieshomecookin. Thank you for reading our article of how long to cook chicken breast in oven at 375.
